Forkhead Box O4 (FOXO4) (C-Term) Peptide
FOXO4
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN977073
Quick Overview for Forkhead Box O4 (FOXO4) (C-Term) Peptide (ABIN977073)
Target
FOXO4
(Forkhead Box O4 (FOXO4))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- TPVLTPPTEA ASQDRMPQDL DLDMYMENLE CDMDNIISDL MDEGEGLDFN
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-FOXO4 Antibody(ARP32110_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- FOXO4 (Forkhead Box O4 (FOXO4))
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Background
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FOXO4 is transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. The protein can down-regulate expression of HIF1A and suppress hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle. A chromosomal aberration involving FOXO4 is found in acute leukemias.
Alias Symbols: AFX, AFX1, MGC120490, MLLT7
Protein Interaction Partner: AKT1,CCND1,CDKN1A,CTNNB1,FOXG1,SMAD3,SMAD4,AKT1,AKT2,CREBBP,CTNNB1,ESR1,FOXG1,SMAD3,SMAD4,XPO1,YWHAZ,CREBBP,CTNNB1,ESR1,MDM2,PIN1,SMAD3,SMAD4,UBC,USP7,XPO1
Protein Size: 505 -
Molecular Weight
- 54 kDa
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Gene ID
- 4303
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NCBI Accession
- NM_005938, NP_005929
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UniProt
- P98177
Target
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